Biosecurity
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The National Plant Diagnostic Network (NPDN) was created to enhance the capabilities of existing diagnostic laboratories in the nation to detect and report introduced pathogens, pests and weeds of high consequence to plant agriculture and natural ecosystems.  An important goal of the network is to coordinate diagnostic and scientific expertise at land-grant universities, state departments of agriculture, agencies within the USDA (CSREES and APHIS), and other organizations involved in agricultural production and security.  The program, which is administered through the USDA, was established in 2002 through funding created by the Homeland Security Act in response to concerns that agricultural pests and pathogens could be used as agents of bio-terrorism.  Responsibilities of the NPDN include the compilation and establishment of diagnostic protocols for priority agents, the development of a web-based distributed plant pest diagnostic and reporting system for the nation, the provision of up-to-date information on plant pests for the nation, the development of analytical tools to exploit these data, and the recruitment and training of first detectors.  The national network is organized into 5 regions, with regional centers located at the University of California, Davis (Western Region), Kansas State University (Great Plains Region), Michigan State University (North Central Region), the University of Florida (Southern Region), and Cornell University (Northeastern Region).  A parallel network for veterinary medicine, the National Animal Health Laboratory Network, also has been established with regional centers located at the same institutions as the NPDN regional centers.  The mission and design of the NPDN, its programs, and progress towards meeting network objectives, will be presented and discussed.

Richard Bostock is a professor and former chair (1999-2005) of the Department of Plant Pathology at the University of California, Davis.  In 2002, he was appointed as the founding Director of the Western Region of the National Plant Diagnostic Network (NPDN).  The NPDN is a distributed system comprised of public institutions for the purpose of quickly detecting and identifying high consequence pests and pathogens.  The network links plant health professionals, researchers and diagnostic labs throughout the region, providing a way for them to share information about occurrences of plant diseases and pests that could have an impact on the region's most economically important crops.   This information also is reported to first responders and decision makers. Funding for the network is provided through the United States Department of Agriculture. Dr. Bostock received his Ph.D. in Plant Pathology at the University of Kentucky in 1981, and was appointed to the faculty at UC Davis that year.  His research and teaching interests are the biochemistry and molecular biology of plant-microbe interactions and general plant pathology.  He teaches several courses in the department and in the Science and Society program on various aspects of plant pathology, plant-microbe interactions, and issues related to food production. 

Reuben W. Hills Conference Room

Richard Bostock Professor of Plant Pathology and Director, Western Plant Diagnostic Network Speaker University of California, Davis
Seminars
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As we find ourselves at the start of the "biological century" with a wealth of potential benefits to public health, agriculture, and global economies, it is almost deliberately naive to think that the extraordinary growth in the life sciences might not be exploited for nefarious purposes. A report published in 2006 by an ad hoc committee of the National Academies of Science recognized that the breadth of biological threats is much broader than commonly appreciated and will continue to expand for the foreseeable future. The nature of these threats, and a set of potential approaches with which to mitigate these threats, will be reviewed.

David Relman, MD, is professor of medicine, and of microbiology and immunology at Stanford University. He is also chief, infectious diseases section, at the VA Palo Alto Health Care System in Palo Alto, California. His research is directed towards the characterization of the human indigenous microbial communities, with emphasis on understanding variation in diversity, succession, the effects of disturbance, and the role of these communities in health and disease.  This work brings together approaches from ecology, population biology, environmental microbiology, genomics and clinical medicine.  In addition, his research explores the classification structure of humans and non-human primates with systemic infectious diseases, based on patterns of genome-wide gene transcript abundance in blood and other tissues. The goals of this work are to recognize classes of pathogen and predict clinical outcome at early time points in the disease process, as well as to gain further insights into virulence. Past scientific achievements include the description of a novel approach for identifying previously-unknown pathogens, the identification of a number of new human microbial pathogens, including the agent of Whipple's disease, and some of the most extensive analyses to date of the human indigenous microbial ecosystem. See http://relman.stanford.edu

Among his other activities, Dr. Relman currently serves as Chair of the Board of Scientific Counselors of the National Institute of Dental and Craniofacial Research (NIH), Chair of the Institute of Medicine's Forum on Microbial Threats (U.S. National Academies of Science), member of the National Science Advisory Board for Biosecurity, and advises several U.S. Government departments and agencies on matters related to pathogen diversity, the future life sciences landscape, and the nature of present and future biological threats.  He co-chaired a three-year study at the National Academy of Sciences that produced a report entitled, "Globalization, Biosecurity, and the Future of the Life Sciences" (2006). He is a member of the American Academy of Microbiology. Dr. Relman received the Squibb Award of the IDSA in 2001, and was the recipient of both the NIH Director's Pioneer Award, and the Distinguished Clinical Scientist Award from the Doris Duke Charitable Foundation, in 2006.

Reuben W. Hills Conference Room

David Relman Professor of Medicine and of Microbiology and Immunology Speaker Stanford University
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Background: A bioterrorism attack with an agent such as anthrax will require rapid deployment of medical and pharmaceutical supplies to exposed individuals. How should such a logistical system be organized? How much capacity should be built into each element of the bioterrorism response supply chain?

Methods: The authors developed a compartmental model to evaluate the costs and benefits of various strategies for preattack stockpiling and postattack distribution and dispensing of medical and pharmaceutical supplies, as well as the benefits of rapid attack detection.

Results: The authors show how the model can be used to address a broad range of logistical questions as well as related, nonlogistical questions (e.g., the cost-effectiveness of strategies to improve patient adherence to antibiotic regimens). They generate several key insights about appropriate strategies for local communities. First, stockpiling large local inventories of medical and pharmaceutical supplies is unlikely to be the most effective means of reducing mortality from an attack, given the availability of national and regional supplies. Instead, communities should create sufficient capacity for dispensing prophylactic antibiotics in the event of a large-scale bioterror attack. Second, improved surveillance systems can significantly reduce deaths from such an attack but only if the local community has sufficient antibiotic-dispensing capacity. Third, mortality from such an attack is significantly affected by the number of unexposed individuals seeking prophylaxis and treatment. Fourth, full adherence to treatment regimens is critical for reducing expected mortality.

Conclusions: Effective preparation for response to potential bioterror attacks can avert deaths in the event of an attack. Models such as this one can help communities more effectively prepare for response to potential bioterror attacks. Key words: bioterror; supply chain; logistics; anthrax; emergency response.

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Medical Decision Making
Authors
GS Zaric
Dena M. Bravata
Jon-Erik Holty
Kathryn M. McDonald
Douglas K. Owens
Douglas K. Owens
Margaret L. Brandeau
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OBJECTIVE: To identify communication needs and evaluate the effectiveness of alternative communication strategies for bioterrorism responses. METHODS: We provide a framework for evaluating communication needs during a bioterrorism response. Then, using a simulation model of a hypothetical response to anthrax bioterrorism in a large metropolitan area, we evaluate the costs and benefits of alternative strategies for communication during a response. RESULTS: Expected mortality increases significantly with increases in the time for attack detection and announcement; decreases in the rate at which exposed individuals seek and receive prophylaxis; increases in the number of unexposed people seeking prophylaxis; and increases in workload imbalances at dispensing centers. Thus, the timeliness, accuracy, and precision of communications about the mechanisms of exposure and instructions for obtaining prophylaxis and treatment are critical. Investment in strategies that improve adherence to prophylaxis is likely to be highly cost effective, even if the improvement in adherence is modest, and even if such strategies reduce the prophylaxis dispensing rate. CONCLUSIONS: Communication during the response to a bioterror attack must involve the right information delivered at the appropriate time in an effective manner from trusted sources. Because the response system for bioterror communication is only fully operationalized once an attack has occurred, tabletop planning and simulation exercises, and other up-front investments in the design of an effective communication strategy, are critical for effective response planning.

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American Journal of Disaster Medicine
Authors
Margaret L. Brandeau
Zaric, G.S.
Freiesleben, J.
Freiesleben, J.
Edwards, F.L.
Edwards, F.L.
Dena M. Bravata
Authors
Sharan Daniel
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David L. Heymann, assistant director-general for communicable diseases and the director general's representative for polio eradication at the World Health Organization (WHO), has joined CISAC as a consulting professor.

Heymann has dedicated much of his career as a medical doctor to investigating and fighting the spread of infectious diseases and mobilizing global efforts to prevent pandemics.

"Dr. Heymann's expertise on threats to health security is a welcome addition to CISAC," Siegfried Hecker, CISAC co-director, said. "He is deeply knowledgeable about the most severe disease-related threats as well as how best to build cooperative international efforts to reduce these threats."

Prior to assuming his current position at WHO, Heymann served as executive director of WHO's Communicable Diseases Cluster, which includes programs on infectious and tropical diseases. In that position, he oversaw the response to Severe Accute Respiratory Syndrome (SARS) in 2003.

Before joining WHO, Heymann worked for 13 years as a medical epidemiologist in sub-Saharan Africa, on assignment with the U.S. Centers for Disease Control. While there, he participated in investigating both the first outbreak of Ebola, in Yambuku (then Zaire) in 1976, and the second outbreak, in Tandala, in 1977. He directed the international response to the Ebola outbreak in Kikwit in 1995. Heymann also spent two years as a medical officer in the WHO smallpox eradication program in India prior to 1976.

Heymann spent two weeks in residence at Stanford last spring, co-hosted by CISAC and FSI, during which he delivered a a talk in FSI's Payne Lecture series. In the lecture, titled "Infectious Diseases across Borders: Public Health Security in the 21st Century," he discussed the collective responsibility to defend public health. He surveyed WHO's efforts to fight emerging and re-emerging infectious disease on every continent.

Among those efforts is a global network of scientists who monitor and collect viruses, sending samples to four WHO collaborating centers for analysis and tracking. This network detected the novel virus H5N1, known as avian flu, in 1997, a disease WHO continues to track closely.

Currently, Heymann said, the H5N1 virus is in the third of six phases in WHO's pandemic alert system, meaning that there have been cases of human infection but "no, or very infrequent, human-to-human spread."

Heymann emphasized, "It is important to prevent the disease at the source." At the same time, WHO is working to "provide universal access to vaccines," which, while not eliminating the disease, "will prevent sickness," he said.

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John Feffer
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WASHINGTON, May 24 (IPS) - This year the Association of Southeast Asian Nations celebrates its 40th birthday, and it has big plans. After four decades of being largely a political and security alliance, ASEAN is accelerating its plans for economic integration.

ASEAN leaders are so eager to pull together into an economic community that they recently decided to move the goalposts. The economic benchmarks originally planned for 2020 have been moved up to 2015.

"The mission of this economic community is to develop a single market that is competitive, equitably developed, and well integrated in the global economy," says Worapot Manupipatpong, principal economist and director of the office of the Secretary-General in the ASEAN Secretariat. He was speaking last week at an Asian Voices seminar in Washington, DC, sponsored by the Sasakawa Peace Foundation.

The single market of 2015 would encompass all ten members of ASEAN: Brunei, Cambodia, Indonesia, Laos, Malaysia, Myanmar (Burma), Philippines, Singapore, Thailand, and Vietnam. According to the projections of the ASEAN Secretariat, the single market will be accomplished by removing all barriers to the free flow of goods, services, capital, and skilled labor. Rules and regulations will be simplified and harmonised. Member countries will benefit from improved economies of scale. Common investment projects, such as a highway network and the Singapore--Kunming rail link, will facilitate greater trade.

Although there will not be a single currency like the European Union's euro, the ASEAN countries will nevertheless aim for greater currency cooperation.

"ASEAN's process of economic integration was market-driven," says Soedradjad Djiwandono former governor of Bank Indonesia, and it was influenced by the "Washington consensus" favoring increased liberalisation. "It is a very different framework from the closed regionalism of the Latin American model," he continues. With multilateral talks on trade liberalisation stalled, efforts have largely shifted to bilateral negotiations. "There has been a proliferation of bilateral agreements that developed countries use as a way to push a program for liberalising different sectors," Djiwandono concludes.

So far, ASEAN points to increased trade within the ten-member community as an early sign of success. But, overall trade share -- 25 percent -- pales in comparison to the 46 percent share of the North American Free Trade Agreement countries or the 68 percent share of EU countries. And with intra-ASEAN foreign direct investment rather low -- only 6 percent in 2005 -- financial integration lags behind trade integration.

The ASEAN approach differs in several key respects from the EU model, which originated in a 1951 coal and steel agreement among six European nations. ASEAN's origins, in contrast, have been primarily political and security-oriented, observes Donald Emmerson, director of the South-east Asia Forum at the Shorenstein Asia-Pacific Research Center at Stanford. "The success attributed to ASEAN is that it presided over an inter-state peace ever since it was formed. There's never been a war fought between ASEAN members."

Also distinguishing ASEAN from EU is the latter's institutionalisation. "ASEAN is radically different," Emmerson continues. "The much discussed ASEAN way is consultation, not even voting, since if they vote, someone will lose. Sometimes the consultation goes on without result. Sometimes decisions are reduced to the lowest common denominator. It also means that rhetoric predominates." This consultative process will be tested in November, when ASEAN leaders gather to adopt a charter, something that the EU has so far failed to accomplish.

Another difference with Europe is the enormous economic disparities among the ASEAN members, with Singapore and Brunei among the richest countries in the world and Laos among the poorest. These economic disparities are reproduced within the countries as well.

Worapot Manupipatpong points to two ASEAN initiatives for closing the gap. There is help for small and medium-sized enterprises. And the Initiative for ASEAN Integration,"basically provides technical assistance to Cambodia, Laos, and Myanmar so that they can catch up with the rest of the ASEAN members," he says. "Attention will be paid to where these countries can participate in the regional networks, what comparative advantage they have, and how to enhance their capacities to participate in the regional development and supply chain."

Then there are ASEAN's efforts to address "public bads," according to Soedradjad Djiwandono. "When there is a tsunami or a pandemic," he argues, "the worst victims are the marginalised or the poor. Addressing that kind of issue has some positive impact on reducing inequality."

"The gap between the early joiners and the later joiners will continue to be substantial because ASEAN has always been more of a forum and less of a problem-solving organisation," observes Karl Jackson, director of the Asian Studies Program at the School for Advanced International Studies at Johns Hopkins University. "As a result one would expect that these gaps would be closed only as individual countries increase their rates of growth." He attributes the inequality within countries to the middle stage of growth experienced by almost all societies: "Inequality increases before the state becomes strong enough to redivide some of the pie and take care of the gross inequalities caused by rapid economic growth."

ASEAN is banking on financial and trade liberalisation increasing the overall regional pie. On paper it is an ambitious project. But "the low hanging fruit have been plucked," says Donald Emmerson. Tariffs on the "easy commodities" have already been reduced to less than 5 percent. But non-tariff barriers to trade remain, and member countries are very protective of certain sectors.

Also tempering the region's optimism is the memory of the Asian financial crisis. The crisis began in Thailand in 1997 and spread rapidly to other countries in the region. One school of thinking holds that capital mobility -- "hot money" -- either caused or considerably aggravated the crisis. Since the ASEAN integration promises greater capital mobility, will the region be at greater risk of another such crisis?

"One consequence of the economic dynamism of the Asia-Pacific region," notes Donald Emmerson, "is that the accumulation of vast foreign exchange reserves -- obviously in China, but in other countries too -- more than anything else represents an asset that can be brought into the equation as a stabilising factor in the event of a financial crisis." Also, he continues, as a result of the ASEAN plus Three network, which adds China, South Korea, and Japan to the mix, the 13 countries have "made serious headway toward establishing currency swap arrangements that would come into play in an emergency on the scale of an Asian financial crisis."

Karl Jackson also looks to currency reforms as a hedge against future crisis. The Thai baht and the Indonesian rupiah are now unpegged currencies. "You will not have a situation in which the central bank of Thailand loses 34 billion US dollars defending the baht," Jackson argues. "Instead, the baht will appreciate or depreciate according to market forces."

But Jackson still remains cautious about the future. He points to the large number of non-performing loans in the Chinese banking sector. Also, there is "this anomaly of the U.S. absorbing two-thirds of the savings coming out of Asia, plugging it mostly into consumption rather than direct investment," he observes. "Eventually there has to be some kind of readjustment. The real value of the dollar must fall." (END/2007)

Reprinted by permission from IPS Asia-Pacific.

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Motivated by the failure of current methods to control dengue fever, we formulate a mathematical model to assess the impact on the spread of a mosquito-borne viral disease of a strategy that releases adult male insects homozygous for a dominant, repressible, lethal genetic trait. A dynamic model for the female adult mosquito population, which incorporates the competition for female mating between released mosquitoes and wild mosquitoes, density-dependent competition during the larval stage, and realization of the lethal trait either before or after the larval stage, is embedded into a susceptible-exposed-infectious- susceptible human-vector epidemic model for the spread of the disease. For the special case in which the number of released mosquitoes is maintained in a fixed proportion to the number of adult female mosquitoes at each point in time, we derive mathematical formulas for the disease eradication condition and the approximate number of released mosquitoes necessary for eradication. Numerical results using data for dengue fever suggest that the proportional policy outperforms a release policy in which the released mosquito population is held constant, and that eradication in approximately 1 year is feasible for affected human populations on the order of 105 to 106, although the logistical considerations are daunting. We also construct a policy that achieves an exponential decay in the female mosquito population; this policy releases approximately the same number of mosquitoes as the proportional policy but achieves eradication nearly twice as fast.

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Proceedings of the National Academy of Sciences
Authors
Michael P. Atkinson
Zheng Su
Nina Alphey
Luke S. Alphey
Paul G. Coleman
Lawrence M. Wein
Lawrence Wein
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One of the world's greatest ethical challenges is the inequities in global health. Life expectancy in the United States is about 80 years and rising, while in many parts of the developing world, particularly in Africa as a result of HIV/AIDS, it is 40 years and falling. On the "bright side," the globalization of life sciences is key force to improve health in the developing world. For example, the rise of the Indian biotechnology industry has improved availability of vaccines and programs like the Grand Challenges in Global Health Initiative funded by the Bill and Melinda Gates Foundation provide hope for upstream discovery science against global health problems. However, on the "dark side," the globalization of life sciences poses risks to global biosecurity including bioterrorism by non-state actors.

This lecture will explore how to optimize the benefits of the "bright side," and mitigate the risks of the "dark side," of the globalization of life sciences. Dr. Singer will argue that the biological case is different from the nuclear case and demands a different approach, and explore the potential role of the United Nations in enhancing global biosecurity.

Peter A. Singer is senior scientist at the McLaughlin Rotman Centre, University Health Network; professor of medicine, University of Toronto; co-director of the Canadian Program in Genomics and Global Health; and a distinguished investigator of the Canadian Institutes of Health Research. He studied internal medicine at the University of Toronto, medical ethics at the University of Chicago, public health at Yale University, and management at Harvard Business School. Between 1995 and 2006, Singer was Sun Life Financial Chair in Bioethics, director of the University of Toronto Joint Centre for Bioethics, and director of the World Health Organization Collaborating Centre for Bioethics at the University of Toronto.

History Corner, Building 200, Room 002

Peter A. Singer Senior Scientist, McLaughlin Rotman Centre, University Health Network, and Professor of Medicine Speaker University of Toronto
Lectures
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