Health and Medicine

FSI’s researchers assess health and medicine through the lenses of economics, nutrition and politics. They’re studying and influencing public health policies of local and national governments and the roles that corporations and nongovernmental organizations play in providing health care around the world. Scholars look at how governance affects citizens’ health, how children’s health care access affects the aging process and how to improve children’s health in Guatemala and rural China. They want to know what it will take for people to cook more safely and breathe more easily in developing countries.

FSI professors investigate how lifestyles affect health. What good does gardening do for older Americans? What are the benefits of eating organic food or growing genetically modified rice in China? They study cost-effectiveness by examining programs like those aimed at preventing the spread of tuberculosis in Russian prisons. Policies that impact obesity and undernutrition are examined; as are the public health implications of limiting salt in processed foods and the role of smoking among men who work in Chinese factories. FSI health research looks at sweeping domestic policies like the Affordable Care Act and the role of foreign aid in affecting the price of HIV drugs in Africa.

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More than 46 million Americans live in poverty and high rates of food insecurity and obesity are also a persistent concern. The Supplemental Nutrition Assistance Program (SNAP), formerly known as food stamps, occupies a central role in the U.S. safety net as the only universal aid program for low income individuals. In this talk, Professor Hilary Hoynes will review the evidence on the two  goals of SNAP: providing income support and improving nutrition. Professor Hoynes will discuss the trends in poverty and inequality in the U.S, and how SNAP affects poverty overall and particularly in the Great Recession. Additionally, she will review the evidence on the impact of SNAP on food insecurity and health. This will include new evidence on how access to social safety net programs in early life affect health and human capital outcomes in adulthood. 


Hilary Hoynes is a Professor of Public Policy and Economics and holds the Haas Distinguished Chair in Economic Disparities. She is the co-editor of the leading journal in economics, American Economic Review. Hoynes received her undergraduate degree from Colby College and her PhD from Stanford University.

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Hilary Hoynes

Hoynes is an economist and specializes in the study of poverty, inequality, and the impacts of government tax and transfer programs on low income families. Current projects include evaluating the impact of the Great Recession across demographic groups, examining the impact of Head Start on cognitive and non-cognitive outcomes, examining the impact of the Earned Income Tax Credit on infant health, and estimating impacts of U.S. food and nutrition programs on labor supply, health and human capital accumulation.

In addition to her faculty appointment, Hoynes has research affiliations at the National Bureau of Economic Research, the UC Davis Center for Poverty Research and the Institute for Fiscal Studies. She sits on the Advisory Board of the Stanford Institute for Economic Policy Research and previously has sat on the National Advisory Committee of the Robert Wood Johnson Foundation Scholars in Health Policy Research Program and the Advisory Committee for the National Science Foundation, Directorate for the Social, Behavioral, and Economic Sciences. Prior to joining the Goldman School she was a Professor of Economics at UC Davis.

Hilary Hoynes Professor of public policy and economics; Haas Distinguished Chair in Economic Disparities, UC Berkeley
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Apikal4D

 

A new study by Stanford researchers indicates adding cardiac resynchronization therapy to an implanted cardioverter-defibrillator (CRT-D) for patients with mild heart failure could increase the quality of life and may be cost-effective.

The study in the Aug. 25 issue of Annals of Internal Medicine finds that for patients with left ventricular systolic dysfunction, and a prolonged QRS duration, such devices would cost $61 700 per QALY gained. This result depends on a mortality reduction from CRT-D and is thus most applicable to patients with NYHA class II symptoms who have a QRS duration of 150 milliseconds or greater, or left bunle branch block.

The authors of the paper, “Cost-Effectiveness of Adding Cardiac Resynchronization Therapy to an Implantable Cardioverter-Defibrillator Among Patients With Mild Heart Failure,” include Stanford cardiologist Christopher Y. Woo and Center for Health Policy/Center for Primary Care and Outcomes Research’s Jeremy Goldhaber-Fiebert, an assistant professor of medicine, and Douglas K. Owens, a professor a medicine and director of the two Stanford health policy centers.

 

The full paper can be found on the AIM website.

 

 

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Lecture in English

Chair:  Deng Minghua, School of Mathematical Science, Peking University

Speaker: Hua Tang, Associate Professor of Genetics, Courtesy Associate Professor of Statistics, Stanford University

 

Genome-wide association studies (GWAS) have become a standard approach for identifying loci influencing complex traits. However, GWAS in non-European populations are hampered by limited sample sizes and are thus underpowered. Can GWAS results in one population be exploited to boost the power of mapping loci relevant in another population? In this talk, I will describe a set of analyses, which address the question, “to what extent does the genetic architecture of a complex trait overlap between human populations?” I will next introduce an empirical Bayes approach, which improves the power of mapping trait loci relevant in a specific minority population through adaptively leveraging multi-ethnic evidence. A case study on plasma lipid concentration will be presented.

Bio: Hua Tang received her BS in Biology from Harvard, and PhD in Statistics, with a minor in Genetics, from Stanford University in 2002. From 2002 to 2006, she was on faculty in the PHS division at the Fred Hutchinson Cancer Research Center. Hua joined the Stanford Genetics Department in 2007. The goals of her research are to better understand the evolutionary forces that have shaped the pattern of genetic variation in humans, as well as to elucidate the genetic architecture of complex traits and diseases in the context of human evolution.

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In a Queen's School of Business (QSB) article, David Chan, an assistant professor of Medicine and CHP/PCOR core faculty member, discusses his new study on the cost of variation in medical practices.  The article shows that large variation in medical testing caused by "weak best practices" leads to greater healthcare spending.  According to Chan, there is significant variation in general medicine practices but little variation in specialty areas, and he found that "worker characteristics and formally learned differences have little role in explaining practice variation, at least within organizations.”  Decreasing practice variation could decrease healthcare spending in the U.S. substantially.

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Professor of Neonatal and Developmental Pediatrics
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Gary L. Darmstadt, MD, MS, is Associate Dean for Maternal and Child Health, and Professor of Neonatal and Developmental Pediatrics in the Department of Pediatrics at the Stanford University School of Medicine. Previously Dr. Darmstadt was Senior Fellow in the Global Development Program at the Bill & Melinda Gates Foundation (BMGF), where he led a cross-foundation initiative on Women, Girls and Gender, assessing how addressing gender inequalities and empowering women and girls leads to improved gender equality as well as improved health and development outcomes. Prior to this role, he served as BMGF Director of Family Health, leading strategy development and implementation across nutrition, family planning and maternal, newborn and child health.

Darmstadt was formerly Associate Professor and Founding Director of the International Center for Advancing Neonatal Health in the Department of International Health at the Johns Hopkins Bloomberg School of Public Health. He has trained in Pediatrics at Johns Hopkins University, in Dermatology at Stanford University, and in Pediatric Infectious Disease as a fellow at the University of Washington, Seattle, where he was Assistant Professor in the Departments of Pediatrics and Medicine. Dr. Darmstadt left the University of Washington to serve as Senior Research Advisor for the Saving Newborn Lives program of Save the Children-US, where he led the development and implementation of the global research strategy for newborn health and survival, before joining Johns Hopkins.

Faculty Affiliate at the Stanford Center on China's Economy and Institutions
Faculty Fellow at the Stanford Center at Peking University, May 2016
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Corporate Affiliate Visiting Fellow, 2015-16
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Qi-Hong Sun is a corporate affiliate visiting fellow at the Walter H. Shorenstein Asia-Pacific Research Center (Shorenstein APARC) for 2015-16.

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A three-week seminar focused on digital health innovation and entrepreneurship in China came to a close last week, culminating in the final pitch presentations from four cross-cultural, entrepreneurial student teams. The winning team, LiveBright, presented a way to improve access to personal counseling in China using digital, peer-to-peer methods, with the mission of reducing stress among students and young professionals.

Sponsored by the Stanford Center at Peking University (SCPKU), the course was developed by Dr. Robert Chang, digital health inventor and Assistant Professor of Ophthalmology at Stanford University, and Ravi Pamnani, medical technology executive and alumnus of Stanford’s Biodesign Innovation Fellowship, a pioneering training program in biomedical innovation.

The hands-on course paired Stanford students with Peking University students in collaborative teams and immersed them in the Chinese healthcare system. Students shadowed physicians and interviewed patients to identify unmet needs and market opportunities. Students then brainstormed solutions and developed rapid prototypes to test their ideas and obtain user feedback. Next, they selected business models to ensure the sustainability of their solutions. Along the way, students got feedback from physicians, digital health entrepreneurs, and investors who evaluated their ideas in real-world contexts.

 

rob and ravi compressed SCPKU seminar instructors, Dr. Robert Chang and Ravi Pamnani.

SCPKU seminar instructors, Dr. Robert Chang and Ravi Pamnani
Courtesy of Stanford University

 

 

Other teams focused on a telemedicine approach to physical therapy, a more convenient way to obtain eyeglasses prescriptions at home, and a novel subscription box service to promote women’s health education.

“We have been really impressed with the outside-the-box thinking that the students have employed to identify new opportunities,” said Dr. Chang. “China has seen tectonic changes in the mobile and consumer internet sectors. With this in mind and given the unique characteristics of the Chinese healthcare system, a digital health revolution is inevitable, and in many ways has already begun. The rest of the world can learn a lot by observing how digital technologies will transform healthcare here in China over the next five years.”

For more information about the seminar, visit http://www.dhealthchina.com/.

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Introduction

The decreasing effectiveness of antimicrobial agents is a growing global public health concern. Low-income and middle-income countries are vulnerable to the loss of antimicrobial efficacy because of their high burden of infectious disease and the cost of treating resistant organisms. We aimed to assess if copayments in the public sector promoted the development of antibiotic resistance by inducing patients to purchase treatment from less well regulated private providers.

Methods

We analysed data from the WHO 2014 Antibacterial Resistance Global Surveillance report. We assessed the importance of out-of-pocket spending and copayment requirements for public sector drugs on the level of bacterial resistance in low-income and middle-income countries, using linear regression to adjust for environmental factors purported to be predictors of resistance, such as sanitation, animal husbandry, and poverty, and other structural components of the health sector. Our outcome variable of interest was the proportion of bacterial isolates tested that showed resistance to a class of antimicrobial agents. In particular, we computed the average proportion of isolates that showed antibiotic resistance for a given bacteria-antibacterial combination in a given country.

Findings

Our sample included 47 countries (23 in Africa, eight in the Americas, three in Europe, eight in the Middle East, three in southeast Asia, and two in the western Pacific). Out-of-pocket health expenditures were the only factor significantly associated with antimicrobial resistance. A ten point increase in the percentage of health expenditures that were out-of-pocket was associated with a 3·2 percentage point increase in resistant isolates (95% CI 1·17–5·15; p=0·002). This association was driven by countries requiring copayments for drugs in the public health sector. Of these countries, moving from the 20th to 80th percentile of out-of-pocket health expenditures was associated with an increase in resistant bacterial isolates from 17·76% (95% CI 12·54–22·97) to 36·27% (31·16–41·38).

Interpretation

Out-of-pocket health expenditures were strongly correlated with antimicrobial resistance in low-income and middle-income countries. This relation was driven by countries that require copayments on drugs in the public sector. Our data suggest cost-sharing of antimicrobials in the public sector might drive demand to the private sector in which supply-side incentives to overprescribe are probably heightened and quality assurance less standardised.

Funding

National Institutes of Health.

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Lancet Infectious Diseases
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Karen Eggleston
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Demographic change is fast becoming one of the most globally significant trends of the 21st century. Declining fertility rates and rising life expectancy -- two of the patterns triggering demographic change -- will cause vast socioeconomic strains, especially in the Asia-Pacific region, which has some of the world's most populous countries. Stanford health researcher Karen Eggleston says comparison and cross-collaboration are needed to induce creative solutions.

In an interview with the Office of International Affairs, Eggleston discusses her research approaches and partnerships in the study of healthcare systems and health policy in the Asia-Pacific region. She leads a multiyear research initative that examines comparative policy responses to demographic change in East Asia. Eggleston says the goal is to help move global health policy to a place where everyone has an "equal opportunity for a healthier and longer life."

The Q&A may be viewed in full by clicking here.

Analyzing demographic change in China, Japan and South Korea is the focus of the book Aging Asiaan outcome of a conference between the Walter H. Shorenstein Asia-Pacific Research Center and the Stanford Center on Longevity.

Eggleston also coedited a special issue of the Journal of the Economics of Ageing with David Bloom, a professor at Harvard University, looking at a range of economic issues related to population change in China and India.

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Karen Eggleston (left) confers with a healthcare worker at a primary care clinic in Hangzhou, China.
Robin Yao
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For Matthew Kohrman and his students, the war against tobacco needs a new communications strategy.

After all, he noted, three times as many cigarettes are currently manufactured and sold worldwide than were in the 1960s. And the global cigarette industry is the greatest cause of preventable death on the planet today.

That’s why the Stanford associate professor of anthropology decided to teach an introductory seminar this spring, Anthro 182N, titled Smoke and Mirrors in Global Health. Kohrman led his 10 students on a journey into the “strange optics” that the global tobacco industry uses – and what to do about them.

As noted in the syllabus, “entrenched challenges” to global health require society to develop “new methods” to communicate the real truth about tobacco.

Just what are those “new methods?” At the culmination of the class, the students presented some variations on that theme. Their end-of-the-quarter projects were web-based efforts profiling various features of global tobacco. They included exposés on how academicians in China assist the industry in that country, humorous parodies and critiques of Philip Morris, and flawed approaches to tobacco control in South Korea.

They tackled big-picture questions, Kohrman said. For example, they asked what exactly constitutes cigarette manufacturing and how new strategies could help slow the spread of tobacco-related diseases worldwide.

Kohrman, the director of Stanford’s Cigarette Citadels project, envisioned his class as a way for students to offer some thought-provoking and original ideas grounded in solid data. After viewing the student projects, he was astounded – and proud.

“My overall impression has been a feeling of awe,” he said. “Mostly freshmen and sophomores, the students who enrolled in this new course quickly synthesized complex intellectual concepts introduced early in the quarter, conceived their own innovative project ideas, collected relevant data, generously worked with each other, designed apt strategies for evocatively visualizing their messages, and chose and implemented strong interactive media tools – most of which were utterly new to me.”

One of those students was Minkee Sohn, a communication major, who created a video, “Fresh Recruits,” to highlight what he believes is the hypocrisy in the language of some cigarette manufacturers’ recruitment efforts.

“While cigarette manufacturers,” Sohn said, “often frame smoking as an act of free choice, that choice is just an illusion. Free choice is denied to people in all stages of cigarette manufacturing and consumption.”

For example, he explained that children in the African country of Malawi are coerced to work with their families in tobacco fields. “It’s deeply disturbing to hear companies associate freedom with high-paying jobs in cigarette manufacturing.”

For biology major Annabel Chen, the most important thing she learned was to analyze information skeptically. “Industries like big tobacco have influences in unexpected places, so you always need to do sleuthing to find out the truth,” she said.

She chose to examine the links between tobacco and academic research in China. “Seeing as China is the biggest tobacco market in the world, this was a problem we needed to address.”

Kohrman appreciates how students like Sohn and Chen were willing to try an experimental course, never taught before, and which for many was outside of their comfort zone. He said the course will be taught again in 2015-16.

“Looking back, it was the perfect-size group for all the work and one-on-one teaching we did,” he said.

The course was a classic collaboration, according to Kohrman, who also credits Claudia Engel, a lecturer in the Anthropology Department who helped with the technology and his own experiences mentoring undergraduate research, all of which proved instrumental to designing Smoke and Mirrors in Global Health.

“It was a great success today,” he said after seeing the student projects on the last day of class. Tom Glynn, a top adviser to the American Cancer Society, was on hand to see the presentations.

Kohrman added, “Students got tremendous feedback, and there was lots of enthusiasm about how this experimental course unfolded.”

Clifton Parker is a writer for the Stanford News Service.

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