Cosponsored by the International Initiative at Stanford University, the United Nations Association Film Festival (UNAFF), the Freeman Spogli Institute for International Studies (FSI), and Global AIDS Interfaith Alliance (GAIA)

Hosted by the International Initiative Human Well-being Working Group, this special event, Endangered Childhood: Disease, Conflict and Displacement, will consist of a documentary film viewing and a scholarly panel discussion. The film Their Brothers' Keepers: Orphaned by AIDS will open the session to provide insight into the plight of children orphaned by AIDS. Moderator Paul Wise and the other panelists will speak on the impact of conflict and displacement, the psychological effects on child health and development, and work done to assist children affected by AIDS. The session will conclude with a Q&A session open to all.

(Photo courtesy of the United Nations Association Film Festival)

This screening is the presentation of the United Nations Association Film Festival special screening events (for more information, please visit www.unaff.org).

Conceived in 1998 at Stanford University by film critic and educator Jasmina Bojic in conjunction with the fiftieth anniversary of the signing of the Universal Declaration of Human Rights, the United Nations Association Film Festival (UNAFF) screens documentaries by international filmmakers dealing with topics such as human rights, environmental survival, women's issues, children, refugee protection, homelessness, racism, disease control, universal education, war and peace. By bringing together filmmakers, the academic community and the general public, UNAFF offers a unique opportunity for creative exchange and education among groups and individuals often separated by geography, ethnicity and economic constraints.

A key pillar and unmet need in the defense against threats to health is the ability to recognize the etiological factor(s) and predict the course of disease, at early points in the timeline of the process. This ability would enable early intervention in the disease process when there is the greatest likelihood of benefit, as well as triaging of hosts, based on individual need. Genomic tools and approaches have enabled a more detailed description of host-microbe encounters, and shed light on fundamentally important processes, including the cellular responses associated with infection. Genome-wide transcript-abundance profiles, like other comprehensive molecular readouts of host physiological state, provide a detailed blueprint of the host-pathogen dialogue during microbial disease. Studies of cancer based on genome-wide transcript-abundance profiles have led to novel signatures that predict disease outcome and serve as useful clinical classifiers. The highly dynamic and compartmentalized aspects of the host response to pathogens complicate efforts to identify predictive signatures for infectious diseases. Yet, studies of systemic infectious diseases so far suggest the possibility of successfully discriminating between different types (classes) of infection and predicting clinical outcome. In addition, host gene expression analysis could lead to the identification of early signatures associated with a protective immune response, both to natural infection and to vaccination. Early explorations in some of these areas indicate the potential feasibility of this approach but also point to important unmet challenges.

David Relman is associate professor of medicine, and of microbiology and immunology at Stanford University. He is also chief, infectious diseases section, at the VA Palo Alto Health Care System in Palo Alto, California.

A native of Boston, Massachusetts, Relman holds an SB degree from the Massachusetts Institute of Technology and received his MD degree, magna cum laude, from Harvard Medical School in 1982. Following postdoctoral clinical training at Massachusetts General Hospital in internal medicine and in infectious diseases, Relman served as a postdoctoral research fellow in microbiology at Stanford University in the laboratory of Stanley Falkow from 1986 until 1992. He joined the Stanford University faculty in 1992 and was appointed associate professor (with tenure) in 2001. His research is directed towards the characterization of the human indigenous microbial communities of the mouth and gut, with emphasis on understanding variation in diversity, succession, the effects of disturbance, and the role of these communities in oral and intestinal disease.

Experimental approaches include molecular phylogenetics, ecological statistics, single cell genomics, and community-wide metagenomics. A second area of research concerns the classification structure of humans and non-human primates with systemic infectious diseases, based on patterns of genome-wide gene transcript abundance in blood and other tissues. The goals of this work are to recognize classes of pathogen and predict clinical outcome at early time points in the disease process, as well as gain further insights into virulence (e.g., of variola and monkeypox viruses). Past achievements include the description of a novel approach for identifying previously-unknown pathogens (selected as one of the 50 most important papers of the last century by the American Society for Microbiology), the identification of a number of new human microbial pathogens, including the agent of Whipple's disease, and the most extensive descriptions to date of the human indigenous microbial community. See http://relman.stanford.edu. Relman received the Squibb Award from the Infectious Diseases Society of America (2001), the Senior Scholar Award in Global Infectious Diseases from the Ellison Medical Foundation (2002), and is a recipient of an NIH Director's Pioneer Award (2006). He is a member of the American Society for Clinical Investigation and was named a Fellow of the American Academy of Microbiology in 2003.

Relman currently serves on the Board of Scientific Counselors of the National Institute of Dental and Craniofacial Research and was a member of the Board of Directors of the Infectious Diseases Society of America (2003-2006), and co-chair of the National Academy of Sciences' Committee on Advances in Technology and the Prevention of Their Application to Next Generation Biowarfare (2004-2006). He is a member of the National Science Advisory Board for Biosecurity, the Institute of Medicine's Forum on Microbial Threats, and advises several U.S. Government departments and agencies on matters related to microbial pathogen detection and future biological threats.

The siting and construction of high-level biocontainment facilities involves a complex review process with environmental impact documents, legally mandated reviews, and public involvement in decision making about associated risks. In some cases, serious public opposition and legal challenges may arise during the review and approval stages of a project. The recent proposed construction of NIH-NIAID regional and national biocontainment labs provided an opportunity for a real-time study of the review and approval processes associated with labs in many different locations. By analyzing environmental impact documents, mass media coverage, internet communications, and detailed timelines at the various labs, it was possible to identify common issues and features associated with labs in general, as well as specific concerns associated with those where public controversies and opposition arose. The study focused on both good and bad experiences at various recently proposed lab sites and compared them with other past case examples to identify 'lessons learned' that are relevant to both current and future biocontainment projects. Overall, the study documented the continuing importance of trust, transparency, and due process in public decision making and highlighted the importance of developing and implementing a comprehensive pro-active risk communication strategy at the earliest stages of project planning. The study also documented indications of public insecurity associated with biodefense research, which may translate into future problems for public health researchers.

Margaret Race is an ecologist working with NASA through the SETI Institute in Mountain View, Calif. She recently completed a study on public decision making and risk communication associated with the construction of BSL-3 and BSL-4 biocontainment labs nationwide. The study, which was begun during a fellowship at Stanford University and CISAC, reflects her longstanding interest in risk perceptions, legal and societal issues, public communication and education associated with controversial science and technological proposals. In her work with NASA, she focuses on planetary protection and the search for extraterrestrial life--which will someday involve construction of a BSL-4 biocontainment lab for handling and testing scientific samples returned from Mars and other solar system locaitons. During the past decade, she has been a lead member of an international team of researchers that helped NASA develop a protocol for the quarantine, handling, and testing of extraterrestrial samples from Mars. She has served on numerous National Resource Council studies analyzing risk communication and societal issues associated environmental protection on Earth and in space. Dr. Race received her BA degree in Biology and MS degree in Energy Management and Policy from the University of Pennsylvania, and her Ph.D. in Ecology/Zoology from the University of California at Berkeley. Her teaching and research work has included positions at Stanford University (Human Biology Program), UC Berkeley (Assistant Dean, College of Natural Resources), and Office of the President, University of California (Senior Science Policy Analyst and Director of Planning). She was also a Postdoctoral Fellow in Marine Policy and Ocean Management at Woods Hole Oceanographic Institution.

An invigorating day of addresses, debate, and discussion of major sources of systemic and human risk facing the global community.