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Timely reunion panel hosted by Stanford president John Hennessy, moderated by Stanford alum Ted Koppel, and featuring Bill Perry and George Shultz.

The final decade of the 20th century was a time of great optimism. The fall of the Iron Curtain ushered in a new era of democracy and freedom for millions. The expansion of the European Union promised to open borders to trade and opportunity. The technology revolutions of the 1990s promised to bridge cultural gaps and unite diverse people.

Yet, in the first decade of the 21st century, this optimism has faded in the face of myriad threats: the menace of terrorism and nuclear proliferation, the danger of virulent pandemics, the global dependence on oil from volatile regions, and the far-reaching and often unsettling implications of an interconnected planet.

In such uneasy times, is it safe to feel safe? What is the way forward in the midst of these challenges? What will it take? What is Stanford doing to help address these issues?

Panelists

John L. Hennessy, Stanford President and Bing Presidential Professor

Jean-Pierre Garnier, MBA '74, CEO, GlaxoSmithKline

The Hon. Anthony M. Kennedy, '58, Supreme Court Justice

William J. Perry, '49, MS '50, former Secretary of Defense, Berberian Professor in the School of Engineering

Dr. Lucy Shapiro, Ludwig Professor of developmental biology and cancer researcher

George P. Shultz, former Secretary of State, Ford Distinguished Fellow, Hoover Institution

Jerry Yang, '90, MS '90, co-founder, Yahoo!

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Background
Multidrug-resistant tuberculosis (MDR-TB) is an important global health problem, and a
control strategy known as DOTS-Plus has existed since 1999. However, evidence regarding the feasibility, effectiveness, cost, and cost-effectiveness of DOTS-Plus is still limited.


Methodology/Principal Findings
We evaluated the feasibility, effectiveness, cost, and cost-effectiveness of a DOTS-Plus pilot project established at Makati Medical Center in Manila, the Philippines, in 1999. Patients with MDR-TB are treated with regimens, including first- and second-line drugs, tailored to their drug susceptibility pattern (i.e., individualised treatment). We considered the cohort enrolled between April 1999 and March 2002. During this three-year period, 118 patients were enrolled in the project; 117 were considered in the analysis. Seventy-one patients (61%) were cured, 12 (10%) failed treatment, 18 (15%) died, and 16 (14%) defaulted. The average cost per patient treated was US$3,355 from the perspective of the health system, of which US$1,557 was for drugs, and US$837 from the perspective of patients. The mean cost per disability-adjusted life year (DALY) gained by the DOTS-Plus project was US$242 (range US$85 to US$426).


Conclusions
Treatment of patients with MDR-TB using the DOTS-Plus strategy and individualised drug
regimens can be feasible, comparatively effective, and cost-effective in low- and middle-income countries.

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PLoS Medicine
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An invigorating day of addresses, debate, and discussion of major sources of systemic and human risk facing the global community.

7:30 AMREGISTRATION
8:00 - 9:00 AMBREAKFAST AND WELCOME
John W. Etchemendy, Provost, Stanford University
Coit D. Blacker, Director, Freeman Spogli Institute

OPENING REMARKS
Warren Christopher, 63rd Secretary of State
William J. Perry, 19th Secretary of Defense
George P. Shultz, 60th Secretary of State
9:15 AM - 12:00 PMMORNING SESSION
PLENARY I
Understanding, Measuring, and Coping with Risk: What We Know Coit D. Blacker, Director, Freeman Spogli Institute, Chair
Understanding and Measuring Risk Elisabeth Paté-Cornell
The Collapse of the Nuclear Non-Proliferation Regime? Scott D. Sagan
Keeping Fissile Materials Out of Terrorist Hands Siegfried S. Hecker

CONCURRENT BREAKOUT SESSIONS
Food Security and the Environment Rosamond L. Naylor, Chair
Pandemics, Infectious Diseases, and Bioterrorism Alan M. Garber, Chair
Insurgencies, Failed States, and the Challenge of Governance Jeremy M. Weinstein, Chair
12:30 - 2:00 PMLUNCHEON
Infectious Diseases, Avian Influenza, and Bioterrorism: Risks to the Global Community
Michael T. Osterholm, Director, Center for Infectious Disease Research and Policy, University of Minnesota
2:30 - 5:30 PMAFTERNOON SESSION
PLENARY II
Natural, National, and International Disasters Michael A. McFaul, Deputy Director, FSI and Director, Center on Democracy, Development, and the Rule of Law, Chair
Terror, U.S. Ports, and Neglect of Critical Infrastructure Stephen E. Flynn
Energy Shocks to the Global System David G. Victor

CONCURRENT BREAKOUT SESSIONS
Responding to a World at Risk: U.S. Efforts at Democracy Promotion in Russia, Iraq, and Iran Michael A. McFaul, Chair
The European Union: Politics, Economics, Terrorism Amir Eshel, Chair
China's Rise: Implications for the World Economy and Energy Markets Thomas C. Heller, Chair
Cross Currents: Nationalism and Regionalism in Northeast Asia Daniel C. Sneider, Chair
6:00 - 8:00 PMCOCKTAIL RECEPTION AND DINNER
Cocktail Reception 6:00 - 7:00 PM
Dinner 7:00 - 8:00 PM
8:00 - 9:00 PMA WORLD AT RISK
Peter Bergen, CNN Terrorism Analyst
Author of Holy War, Inc.: Inside the Secret World of Bin Laden
Paul H. Nitze School of Advanced International Studies, Johns Hopkins University

Frances C. Arrillaga Alumni Center

Conferences

Philippines Conference Room

Shorenstein APARC
Stanford University
Encina Hall, Room E301
Stanford, CA 94305-6055

(650) 724-6402 (650) 723-6530
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Visiting Scholar
PhD

Stella Quah, (PhD, University of Singapore; M.Sc [sociology], Florida State University) is professor of sociology at the National University of Singapore. She was a Fulbright Hays scholar from 1969 to 1971. Since 1986 she has spent academic sabbaticals as research associate and visiting scholar at the Institute of Governmental Studies, University of California Berkeley; the Center for International Studies at the Massachusetts Institute of Technology; the Department of Sociology at Harvard University; the Harvard-Yenching Institute, Harvard University; the Stanford Program in International Legal Studies, Stanford University; and the National Centre for Development Studies, Australian National University.

Professor Quah was elected vice president for research of the International Sociological Association (ISA); chairperson of the ISA Research Council for the session 1994-98; and served as associate editor of International Sociology (1998-2004).

Among her professional activities, Professor Quah serves on two institutional review boards; is member of the Society for Comparative Research; member of the International Advisory Board of the British Journal of Sociology; member of the Editorial Advisory Board of Health Sociology Review, the journal of the health section of the Australian Sociological Association; member of the editorial board of Marriage & Family Review; member of the International Advisory Board of Asian Population Studies; editor of the Sociology in Asia Series; and editor of the Health Systems Section, Encyclopedia of Public Health (Elsevier Inc).

Professor Quah's main areas of research are medical sociology, social policy, and family sociology. The complete list of her publications is at http://profile.nus.edu.sg/fass/socquahs.

Stella Quah Visiting Scholar, Shorenstein APARC, Stanford and Professor, Department of Sociology National University of Singapore Speaker
Jim Whitman Director, MA Programme, Department of Peace Studies, School of Social and International Studies, Speaker University of Bradford, United Kingdom
Chris Beyrer Director, Johns Hopkins Fogarthy AIDS International Training and Research Program, Director, Johns Hopkins Center for Public Health and Human Rights, Speaker Johns Hopkins Bloomberg School of Public Health
Graham Scambler Director, Unit of Medical Sociology, and Deputy Director,The Centre for Behavioural and Social Sciences in Medicine, Department of Medicine, Faculty of Clinical Sciences Speaker University College London
Kari Hartwig Division of Global Health, Dept of Epidemiology and Public Health Speaker Yale School of Medicine
DK Owens Speaker
Gabriel M. Leung Department of Community Medicine, Faculty of Medicine Speaker University of Hong Kong
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This issue of CHP/PCOR's quarterly newsletter, which covers news from the fall 2005 quarter, includes articles about:

  • a study concluding that the implantable cardioverter defibrillator -- one of the most expensive medical devices on the market -- is worth its high cost, in appropriate patients, because it prevents sudden cardiac deaths;
  • the evolution and broad application of the Quality Indicators, a set of practical tools developed by CHP/PCOR researchers that are used by hundreds of U.S. hospitals, medical groups, health insurers, state health agencies and business coalitions to screen for quality problems;
  • a study finding that the Internet can be a valuable tool to help patients with stigmatized illnesses (such as mental illness) find information about and seek treatment for their illness;
  • CHP/PCOR-hosted seminars on global health themes, given by Jack Chow of the World Health Organization -- who discussed combating malaria, TB and HIV/AIDS -- and Dean Jamison of the NIH's Fogarty International Center, who discussed evaluating countries' performance on health; and
  • a prestigious national award won by two CHP/PCOR trainees at the annual meeting of the Society for Medical Decision Making.
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