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Abstract: Recent advances in synthetic biology are transforming our capacities to make things with biology. This bio-based manufacturing technology has the potential to be most disruptive around products for which existing material supply chains result in limited access. For example, broad access to medicines and the development of new medicines has been difficult to achieve, largely due to the coupling between material supply chains and these therapeutic compounds. We are developing a biotechnology platform that will allow us to replace current supply chains for already approved medicines with stable, secure, scalable, distributed, and economical microbial fermentation. Our initial target is the opioids, an essential class of medicines for pain management and palliative care, which are currently sourced through opium poppy cultivation. In addition, we will leverage this technology to access novel compound structural space that will open up tremendous opportunity for transforming the discovery and development of new drugs over a longer-time frame.

About the Speaker: Christina D. Smolke is an Associate Professor, Associate Chair of Education, and W.M. Keck Foundation Faculty Scholar in the Department of Bioengineering and, by courtesy, Chemical Engineering at Stanford University. Christina’s research program develops foundational tools that drive transformative advances in our ability to engineering biology. For example, her group has led the development of a novel class of biological I/O devices, fundamentally changing how we interact with and program biology. Her group uses these tools to drive transformative advances in diverse areas such as cellular therapies and natural product biosynthesis and drug discovery. Christina is an inventor on over 15 patents and her research program has been honored with numerous awards, including the NIH Director’s Pioneer Award, WTN Award in Biotechnology, and TR35 Award.

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Christina Smolke Associate Chair for Education, Associate Professor, Bioengineering Speaker Stanford University
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Elizabeth Blake, Habitat for Humanity International’s General Counsel and team leader of its Government Relations and Advocacy operations, spoke to students at the Freeman Spogli Institute on February 25 as part of the Program on Human Rights Winter Speaker Series that examined U.S Human Rights NGO’s and International Human Rights. 

Habitat for Humanity is a Christian not-for-profit organization that started in 1974 with the credo that every person has a human right to secure shelter and tenure of land. Most of its work is overseas, where Habitat for Humanity has built homes for over 3 million people in over 70 countries. Using security of tenure as its cornerstone, it especially assists women and children who are the most vulnerable to homelessness and insecure tenure. Habitat for Humanity has also recently expanded into housing microfinance, water and sanitation, risk reduction and response, and in creating Habitat Resource Centers.    

Blake’s provocative starting salvo was that “NGOs often do harm and frequently waste money.” Instead, they need to work better among themselves and invite partnerships with other NGOs, governments, and multi-lateral partners. This is not simply a moral imperative but also a practical necessity given the size of the U.S. not-for-profit sector, which as an employer of 13 million people is a significant part of the national economy.   

Habitat for Humanity’s approach maximizes its impact abroad through four principles:

1.     Community development starts with its people – people are the true assets;

2.     International community development must be based upon priorities set by the local community itself;

3.     The test of success of any community development is that local capacity is improved; and

4.     “Accompaniment” – a term first coined by Paul Farmer of Partners in Health: Habitat for Humanity works with and works for the people of that community.

This last principle is the most important: Habitat for Humanity has 1 million volunteers each year who work together with communities, or as Blake says, “scraping walls together with people from a local community is a different relationship to handing out soup” and ensures “going from aid to empowerment.”

Responding to questions from Dana Phelps, program associate for the Program on Human Rights and moderator of the event, Blake emphasized the relevance of her corporate background to working in the non-profit world.  As a graduate of Columbia University’s School of Law, she brings her extensive corporate experience to her work at Habitat, and stressed that “non-profits are businesses – a major corporate undertaking” for which her business background had trained her “not to take no for an answer.” 

Blake also explained that while Habitat for Humanity is a multi-denominational Christian organization, it is not registered as a church.  This means it is subject to anti-discrimination laws in its hiring practices and daily operations. It does not engage in prosthletyzing but instead sees itself as a morals-based organization.   

When Blake was further pressed on how “accompaniment” works in practice, she emphasized that Habitat for Humanity does not impose its values and morals on communities, but instead has intentionally slow processes that ensure communities adapt new practices in their own time. For example, when questioned on the impact of gender-equality housing improvements, Blake said, “Habitat for Humanity doesn’t make the first running – it tends to go in to communities that are already taking the running on gender equality.” 

Helen Stacy, Director of the Program on Human Rights

 

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Elizabeth Blake, former SVP of Habitat for Humanity, speaks at Stanford
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A rapidly aging population poses serious challenges for many countries around the world, particularly in Asia, home to the most populous countries. China and India account for nearly 36% of the world’s population, and are expected to face social and economic complications from demographic change in the next decades.

A special issue of the Journal of the Economics of Ageing explores these trends in a comparative perspective, “The Economic Implications of Population Ageing in China and India” (December 2014), co-edited by David Bloom, a professor at Harvard University’s School of Public Health, and Karen Eggleston, a Center Fellow at the Shorenstein Asia-Pacific Research Center.

“Population ageing represents uncharted waters for China and India,” Bloom and Eggleston write in their coauthored introduction.

The special issue is a collection of 10 articles that examine the economic benefits and potential dilemmas arising from decreased fertility and increased life expectancy, two trends that will impact the development and future trajectories of China and India at the micro- and macroeconomic levels.

Dropping or continued low birth rates imply fewer young people to refresh the labor market. But will this cause the workforce to shrink to an unsustainable level? Demand will increase for health care, long term care, and other social services that support the elderly. What must the government do to ensure adequate access to care?

Empirical data and commentary presented in the special issue seek to inform stakeholders about emerging patterns, and to provide insight on how to best address related policy challenges going forward.

“By adopting responsive behaviors and consultative institutions that address the challenges of population ageing in ways that are appropriate to their unique circumstances, China and India could reap the full economic and social benefits of longer, healthier lives,” they write.

The special issue includes an introduction by Bloom and Eggleston, a feature interview with Richard Suzman, and additional analysis by noted global health experts following each article. The titles and authors of the 10 original research articles are listed below:

  • Intergenerational co-residence and schooling (Anjini Kochar)
  • Regional disparities in adult height, educational attainment, and late-life cognition: Findings from the Longitudinal Aging Study in India (LASI) (Jinkook Lee, James P. Smith)
  • Healthy aging in China (James P. Smith, John Strauss, Yaohui Zhao)
  • Gender differences in cognition in China and reasons for change over time: Evidence from CHARLS (Xiaoyan Lei, James P. Smith, Xiaoting Sun, Yaohui Zhao)
  • Reprint of: Health outcomes and socio-economic status among the mid-aged and elderly in China: Evidence from the CHARLS national baseline data (Xiaoyan Lei, Xiaoting Sun, John Strauss, Yaohui Zhao, Gonghuan Yang, Perry Hu, Yisong Hu, Xiangjun Yin)
  • Should China introduce a social pension? (Bei Lu, Wenjiong He, John Piggott)
  • China’s age of abundance: When might it run out? (Yong Cai, Feng Wang, Ding Li, Xiwei Wu, Ke Shen)
  • The macroeconomic impact of non-communicable diseases in China and India: Estimates, projections, and comparisons (David E. Bloom, Elizabeth T. Cafiero-Fonseca, Mark E. McGovern, Klaus Prettner, Anderson Stanciole, Jonathan Weiss, Samuel Bakkila, Larry Rosenberg)
  • Economic development and gender inequality in cognition: A comparison of China and India, and of SAGE and the HRS sister studies (David Weir, Margaret Lay, Kenneth Langa)
  • Comparing the relationship between stature and later life health in six low and middle income countries (Mark E. McGovern)

The special issue of the Journal of the Economics of Ageing, vol. 4, pages 1-154 (December 2014) is available through Elsevier’s online platform ScienceDirect.

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Asia health policy scholar Karen Eggleston (Center Right) learns about a digital health information system in a visit to a primary care center in Hangzhou, China in Oct. 2014.
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Speaker Bio

14120 Michael Callen
Michael Callen

Assistant Professor, Public Policy

Harvard Kennedy School

 

 

Michael Callen is assistant professor of public policy at the Harvard Kennedy School of Government. His recent work uses experiments to identify ways to address accountability and service delivery failures in the public sector. He has published in the American Economic Review, the Journal of Conflict Resolution, and the British Journal of Political Science. He is an Affiliate of Evidence for Policy Design (EPoD), the Bureau for Research and Economic Analysis of Development (BREAD), the Jameel-Poverty Action Lab (J-PAL), the Center for Effective Global Action (CEGA), the Center for Economic Research Pakistan (CERP), Empirical Studies of Conflict (ESOC), and a Principal Investigator on the Building Capacity for the Use of Research Evidence (BCURE): Data and evidence for smart policy design project. His primary interests are political economy, development economics, and experimental economics.

This event is part of the Liberation Technology Seminar Series

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School of Education

Room 128

Michael Callen Assistant Professor, Public Policy, Harvard Kennedy School
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Abstract:  Foreign aid for health in low- and middle-income countries has increased five-fold over the past 25 years.  Between 2005 and 2010, health aid made up more than 30% of all health spending in low-income countries.  Global health is also an increasingly important component of U.S. foreign aid, rising steadily from under 4% of all U.S. non-military aid in 1990 to 22.7% in 2011.  There is growing evidence for the role of health aid in improving health among recipient countries, but is that it?  In this talk I will address the arguments for and against health as a focus of aid efforts and present initial evidence on the role of health aid on human capital and economic development.

Encina Commons, Room 102,
615 Crothers Way,
Stanford, CA 94305-6019

(650) 723-0984 (650) 723-1919
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Professor, Medicine
Professor, Health Policy
Senior Fellow, by courtesy, Freeman Spogli Institute for International Studies
Senior Fellow, Woods Institute for the Environment
eran_bendavid MD, MS

My academic focus is on global health, health policy, infectious diseases, environmental changes, and population health. Our research primarily addresses how health policies and environmental changes affect health outcomes worldwide, with a special emphasis on population living in impoverished conditions.

Our recent publications in journals like Nature, Lancet, and JAMA Pediatrics include studies on the impact of tropical cyclones on population health and the dynamics of SARS-CoV-2 infectivity in children. These works are part of my broader effort to understand the health consequences of environmental and policy changes.

Collaborating with trainees and leading academics in global health, our group's research interests also involve analyzing the relationship between health aid policies and their effects on child health and family planning in sub-Saharan Africa. My research typically aims to inform policy decisions and deepen the understanding of complex health dynamics.

Current projects focus on the health and social effects of pollution and natural hazards, as well as the extended implications of war on health, particularly among children and women.

Specific projects we have ongoing include:

  • What do global warming and demographic shifts imply for the population exposure to extreme heat and extreme cold events?

  • What are the implications of tropical cyclones (hurricanes) on delivery of basic health services such as vaccinations in low-income contexts?

  • What effect do malaria control programs have on child mortality?

  • What is the evidence that foreign aid for health is good diplomacy?

  • How can we compare health inequalities across countries? Is health in the U.S. uniquely unequal? 

     

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China’s State Council has put forth draft legislation that would ban smoking in public spaces, part of the government’s larger advocacy efforts to help curb tobacco use nationwide. Matthew Kohrman, a professor of anthropology at Stanford University, said it’s a step forward but the ban’s long-term success would depend on local enforcement.

Despite popular belief, global cigarette production has tripled worldwide since the 1960s. Leading the surge has been China.

“China has become the world’s cigarette superpower,” said Kohrman, in an interview on National Public Radio’s program, Marketplace.

Moreover, local governments in China have become dependent on tax revenues generated from tobacco sales, thus reinforcing the cigarette’s ubiquity and ease of access.

China has implemented smoking bans in the past, but with varied success. Now rising healthcare costs caused by tobacco-related diseases are creating urgency for new regulations.

“Whether or not these new regulations will be enforced will, in the end, come down to local politics,” he said.

Matthew Kohrman is part of the Asia Health Policy Program at the Shorenstein Asia-Pacific Research Center, and leads the project, Cigarette Citadels, a peer-sourced mapping project that compiles more than 480 cigarette factories globally.

The full audioclip is available on the Marketplace website.

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A cigarette stand in Shantou, China.
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The study provides evidence that a country’s ability to reduce the gap in child-mortality rates is related to good governance.

The child-mortality gap has narrowed between the poorest and wealthiest households in a majority of more than 50 developing countries, a new study from the Stanford University School of Medicine has found.

This convergence was mostly driven by the fact that child-mortality rates declined the fastest among the poorest families. In the countries where the gap increased, the study identified a common thread: poor governance.

The findings provide important information for making decisions about prioritizing global health investments to effectively promote equity, said Eran Bendavid, MD, assistant professor of medicine, core faculty member at CHP/PCOR, and the study’s author.

The study, published online Nov. 10 in Pediatrics, analyzed data from nearly 1 million families living in 54 low- and middle-income countries to determine the relationship between mortality in children under the age of 5 and wealth inequality.

“In many countries, national wealth has increased hand-in-hand with increasing health inequality. That’s been a signature of our time,” Bendavid said. “It’s a pressing concern for many societies, especially in wealthy countries, but it’s also been an issue in low- and middle-income countries.”

Assessing child mortality within developing countries

Many studies have assessed the national child mortality trends in developing countries, but they say little about the mortality gap between the poorest and wealthiest within those countries. National trends could be associated with either narrowing or widening gaps between the poorest and wealthiest populations, Bendavid noted. For example, if child mortality decreases faster among the wealthy compared with the poor, the overall child-mortality rate in that country could decrease even as the mortality gap widens. Alternatively, if child mortality decreases faster among the poor, the health gap could narrow.

To fill this gap in knowledge, the study sought to understand whether developing countries are experiencing a widening or narrowing mortality-rate gap among children under 5 of the poorest and wealthiest families.

To compare wealth status and under-5 child mortality within a country, Bendavid used data from the demographic and health surveys for 1.2 million women living in 929,224 households in 54 developing countries. The women provided information about their children’s survival status. 

 “The people who conduct these surveys, they’re intrepid surveyors,” said Bendavid, who is also a core faculty member of Stanford Health Policy, which is part of the Freeman Spogli Institute for International Studies. “They reach remote villages up the Congo basin and in the Sahel in Niger, and track the heads of households and women for these in-depth interviews.”

The surveys include information about each woman’s birth histories, including detailed birth registries documenting millions of children. With this information, Bendavid could estimate the probability of a child dying before reaching age 5 per 1,000 live births.

Tallying household possessions

Determining each household’s wealth status was not as straightforward as reviewing annual income and tax returns, which don’t exist in the countries involved in the study. “These surveys tally the possessions in the household. What is the floor made of? What is the roof made of?” Bendavid said. “You can get a wide distribution of household possessions that reflects to a large degree the household wealth.”

Next, Bendavid developed a three-tier wealth index using the household assets. The three wealth categories were relative — poorest, middle and wealthiest.

To analyze trends in wealth status and under-5 mortality, Bendavid looked at all developing countries that had completed the surveys in two specific time frames: 2002-07 and 2008-12. The study found that the under-5 mortality rates among the poorest groups had decreased the most rapidly. The average decline was 4.36 deaths each year per 1,000 live births among the poorest, 3.36 among the middle and 2.06 among the wealthiest. Because the poorest group’s mortality rate is decreasing more quickly that the other groups, the gap in child-mortality rates is closing.

This is good news, Bendavid said. However, not all countries followed this same trend. In a quarter of the surveys examined by the study, inequality in under-5 mortality increased over time.

Bendavid found that four factors were present in countries with a narrowing child-mortality gap: government effectiveness, rule of law, control of corruption and regulatory quality. He found that the difference in mortality rates was significantly associated with the governance score: Better governance scores were related to greater convergence in mortality rates among the three wealth groups.

Benefits from controlling communicable diseases

Bendavid said the evidence in this study is consistent with gains in controlling communicable diseases, such as malaria, measles, diarrhea and respiratory illnesses, that preferentially affect the poorest. Over the past decade, international health aid organizations have financed interventions for these diseases at a high rate.

It makes a persuasive case that these improvements have often begun to benefit the poor even more than the better-off.

“Dr. Bendavid’s study is an important contribution to knowledge about child health improvements in the developing world,” said Davidson Gwatkin, a senior fellow at the Results for Development Institute and a senior associate at Johns Hopkins Bloomberg School of Public Health. “It makes a persuasive case that these improvements have often begun to benefit the poor even more than the better-off.” Gwatkin was not involved in the study.

The study also raises questions about the role of foreign aid institutions in low- and middle-income countries. While the aid efforts are making a difference in child-mortality rates in countries with effective governments, the study seems to show that this is not the case in nations with poor governance, Bendavid said.

“We have the technologies, we have the means, we have the know-how to reduce child mortality dramatically,” said Bendavid. “Even for such low-hanging fruit, however, implementation is not always easy. You have to have government that enables basic safety, and the ability to reach poor and rural communities that benefit from these kinds of programs.”

This work was supported by the National Institute of Allergy and Infectious Diseases (grant KOIAI084582), the Doris Duke Charitable Foundation and the Dr. George Rosenkranz Prize for Health Care Research in Developing Countries.

 Information about Stanford’s Department of Medicine, which also supported this research, is available at http://medicine.stanford.edu.

 

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A middle class is emerging in China, and simultaneously, its population is rapidly aging. These two phenomena are impacting the country’s traditional consumer habits, including spending on healthcare. Experts say private-sector services are one important part of the future of China’s healthcare system, and perhaps also a sign of what’s to come for other countries in the region. Entrepreneurs can provide innovative services that cater widely to consumers and support a shift toward integrated care for health promotion and long-term management of chronic disease, also supplementing resources available in traditional public facilities.

Three experts visited the Walter H. Shorenstein Asia-Pacific Research Center and shared perspectives on those trends at the panel discussion, “Healthcare Entrepreneurs in East Asia: Innovations in Primary Care and Beyond,” hosted by the Asia Health Policy Program.

Historically, healthcare services in China have been almost entirely government-run. A patient would go to a public clinic, stand in a queue, and receive treatment within a few hours – being referred elsewhere if additional treatment was required.

Now, the private sector is growing, based on the promise of improved care and an enhanced experience, both removing the waiting line and ushering in new technologies. The government has also issued several policies encouraging “social capital” investment in health and fitness services.

The private sector for preventative care services now holds around fifteen percent of the entire marketplace in China, and “is expected to get much bigger over the next five years,” said Lee Ligang Zhang, the founding chairman and chief executive officer of iKang, a healthcare group based in Beijing.

Zhang oversees the company’s operation of 50 self-owned healthcare centers and an extended network of 300 affiliates. iKang is one of many groups catering to a growing consumer base of corporate workers and senior managers seeking care outside of the public system.

Comparative view

Increased development of premium healthcare facilities is not only emerging in China, but also in neighboring Taiwan. Since 1995, Taiwan implemented a national health insurance system, and has been lauded for its success in service provision.

Taiwan transitioned its healthcare market to universal coverage. Under this system, a patient can essentially “shop around” and select where to go for services, most of which are covered under the country’s insurance collective system at public or private providers.

“On average, every Taiwanese goes to see a doctor 14 times a year, compared to five times a year in the United States, and two times [a year] in China,” said Dr. Fred Hun-Jean Yang, a physician and chairman of MissionCare, Inc.

Such numbers reflect the higher availability of services compared to China, he said. Even as a small island, Taiwan has over 15,000 clinics and the price for services is generally affordable for the average citizen. Despite this availability of public and private services, Taiwan’s newer healthcare entrepreneurs seek to fill a market demand shaped by similar factors as in China. Yang says technology and the efficiency of the private sector healthcare system is attracting new consumers.

Missioncare is headquartered in northern Taiwan’s Taoyuan City and consists of four community hospitals with a larger network of clinics across the country as well as coordinated long-term care services for the elderly and those with chronic disease. The group has already expanded into China, and plans to integrate healthcare innovations, such as wearable monitoring and mobile payment.

Patient-centric service

Chinese citizens, particularly those with greater expendable income, are more willing to pay out-of-pocket for an improved patient experience, the panelists said.

“The consumer psyche is important,” said Dr. Wei Siang Yu, the founder of the Borderless Healthcare Group (BHG), a group of companies based in Singapore that focuses largely on health telecommunications.

One perspective is that consumers desire a “high-end” environment made possible by tailored design aesthetics and effective branding. Guided by this trend, Yu, a business executive and physician by training, started the “smart cities, smart homes” initiative at BHG.

BHG is now launching an incubator model in Shanghai, which combines intelligent design aesthetics with patient care, and is planning to localize such centers across China. The model is referred to as an “experience center,” rather than a hospital or clinic, and healthcare services – examinations, operations and value-added activities like wellness and education activities – are all centralized in one location.

Looking ahead, Yu said healthcare is likely to move even further away from the traditional hospital setting, and more toward experiential and home-based care models.

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(L to R): Wei Siang Yu, founder of Borderless Healthcare Group; Lee Ligang Zhang, chairman and CEO of iKang Healthcare Group; and Fred Hung-Jen Yang, chairman of Missioncare, Inc. discuss healthcare innovation at the Walter H. Shorenstein Asia-Pacific Center.
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